Aspidon/Aspidon OS Drug Interactions

Aspidon: 2 mg: Pharmacokinetic-related Interactions: The dose of risperidone should be adjusted when used in combination with CYP2D6 enzyme inhibitors (e.g., fluoxetine, and paroxetine) and enzyme inducers (e.g., carbamazepine). Dose adjustment is not recommended for risperidone when co-administered with ranitidine, cimetidine, amitriptyline, or erythromycin.
Effect of Risperidone on other drugs: Risperidone does not show a clinically relevant effect on the pharmacokinetics of lithium, valproate, digoxin or topiramate.
Pharmacodynamic-related Interactions: Centrally-Acting Drugs and Alcohol: Given the primary CNS effects of risperidone, caution should be used when risperidone is taken in combination with other centrally-acting drugs and alcohol.
Drugs with Hypotensive Effects: Because of its potential for inducing hypotension, risperidone may enhance the hypotensive effects of other therapeutic agents with this potential.
Levodopa and Dopamine Agonists: Risperidone may antagonize the effects of levodopa and dopamine agonists.
Clozapine: Chronic administration of clozapine with risperidone may decrease the clearance of risperidone.
Aspidon OS: As with other antipsychotics, caution is advised when prescribing risperidone with medicinal products known to prolong the QT interval, e.g., class Ia antiarrhythmics (e.g., quinidine, dysopiramide, procainamide), class III antiarrhythmics (e.g., amiodarone, sotalol), tricyclic antidepressant (i.e., amitriptyline), tetracyclic antidepressants (i.e., maprotiline), some antihistaminics, other antipsychotics, some antimalarials (i.e., quinine and mefloquine), and with medicines causing electrolyte imbalance (hypokalemia, hypomagnesemia), bradycardia, or those which inhibit the hepatic metabolism of risperidone.